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16:30 - 17:30 19 January 2012
Yale UCL Collaborative Senior Scientist Lecture Series : Small Molecule Control of Intracellular Protein Levels
Christopher Ingold Auditorium |
Christopher Ingold Building
Gordon Street | WC1H 0AJ |
Admission: This event is free and open to all, but places will be allocated on a strictly 'first come, first served' basis.
Ticketing: Pre-booking essential
Professor Craig Crews, Professor of Molecular, Cellular, and Developmental Biology, Yale University, Craig Crews received his B.A. in Chemistry from the University of Virginia and his Ph.D. in Biochemistry from Harvard. After postdoctoral training in the Department of Chemistry and Chemical Biology at Harvard, Dr. Crews joined the Yale faculty in 1995, where is a Professor in the Departments of Molecular, Cellular, and Developmental Biology, Chemistry, and Pharmacology.
Since less than 20% of the proteome has enzymatic activity and current drug development efforts rely heavily on the identification of enzymatic inhibitors, a significant fraction of the proteome, aka ‘The Undruggable Proteome' is currently being ignored. To address this bottleneck in therapeutic development, the Crews lab has developed a technology known as PROteolysis TArgeting Chimera molecules (PROTACs) that can selectively knock down intracellular levels of a specific protein. These cell permeable hetero-bifunctional molecules utilize the cells’ own ubiquitin/proteasome protein degradation pathway to selectively destroy a target protein of choice, thus allowing one to target those proteins that are currently not ‘pharmacologically vulnerable’.
Professor Jeremy Brockes
+44 20 7679 4483 | email@example.com
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