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14:00 - 15:00 2 November 2017

Parametric Working Memory in Rats and its Multiple Timescales: Athena Akrami


Ground floor Lecture Theatre, Sainsbury Wellcome Centre (link Map)
25 Howland Street | London | W1T 4JG | United Kingdom

Open to: Academic | Student

Athena will present her postdoctoral research on rat Parametric Working Memory (PWM), and show formal algorithmic behavioural analysis, optogenetic inactivations, and electrophysiological recordings to suggest Posterior Parietal Cortex (PPC) as a central node in the representation and use of prior sensory experience in PWM. Earlier proposals that PPC supports working memory predict that optogenetic silencing of the PPC leads to a behavioural impairment in working memory task. Contrary to this, silencing PPC produced significant performance improvement. Quantitative analyses of behaviour revealed that this improvement was due to the selective reduction of the effects of prior sensory stimuli. Electrophysiological recordings showed PPC neurons carried more information about sensory stimuli of previous trials than about stimuli of the current trial. Together, the data reveal the PPC as a causally necessary and important node in representation and use of prior sensory stimulus information.


April Cashing-Garbutt
020 3108 8028 | a.cashin-garbutt@ucl.ac.uk