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10 September 2015
The Serine-Threonine Kinase, Tpl2, is Required for Neutrophil Antimicrobial Functions
Royal Free Campus
Rowland Hill Street | Hampstead | London | NW3 2PF | United Kingdom
Speaker: Nicole Acuff, PhD candidate at the University of Georgia (USA).
Nicole Acuff is currently working towards the completion of her doctoral degree in the laboratory of Dr. Wendy Watford at the University of Georgia. Her research focuses on the immunoregulatory properties of the serine/threonine kinase, Tpl2. Because Tpl2 enhances inflammation by promoting expression of cytokines, chemokines and other inflammatory mediators, Tpl2 inhibitors are being investigated as therapeutics for treating autoimmune diseases. Nicole is specifically investigating how Tpl2 regulates to the differentiation and effector functions of inflammatory Th17 cells, including neutrophil recruitment and functions. Information gleaned from these studies should help to understand how Tpl2 contributes to host defense and immunopathology.
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