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15:00 - 16:00 28 January 2015
Division of Psychiatry seminar: Stem cell models of frontotemporal dementia
Cruciform B404 LT2 |
UCL Main Campus | London | United Kingdom
Dr Selina Wray, Alzheimer's Trust Research Fellow, UCL, I am involved in multiple projects investigating the molecular mechanisms of frontotemporal lobar degeneration. My research continues to have a particular focus on tau-mediated neurodegeneration and I was recently awarded a research fellowship from the Alzheimer’s Research Trust to support this work.
Recent developments have made it possible to generate stem cells from other cell types, including fibroblasts. By making stem cells from patents with genetic forms of dementia or other neurological diseases, and differentiating them into neurons, it is possible to make human, neuronal models of disease than can be used to understand the molecular mechanisms of disease and develop new treatments. I will describe the generation of a fibroblast cell bank from patients with genetic causes of neurological disease, and how stem cells made from these patients are being used to model genetic forms of dementia linked to mutations in MAPT, C9orf72 and VCP. I will demonstrate some of the advantages and disadvantages of this approach to disease modelling and look ahead to how these models can help us better understand disease and aid the development of novel therapeutics.
020 7679 9467 | firstname.lastname@example.org