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13:00 - 14:00 7 February 2013

Investigation of cortical MTR abnormalities in MS clinical subgroup


Gilliatt Lecture Theatre | Institute of Neurology (link Map)
Queen Square | London | WC1N 3BG |

Open to: Academic | Student

Speaker information: Dr Becky Samson, Queen Square MS Centre, NMR Research Unit, UCL ION. Host: UCL Institute of Neurology.

Abstract: Histopathology has demonstrated extensive cortical grey matter (GM) damage including demyelination and neuronal loss in multiple sclerosis (MS), particularly in the outer (subpial) cortex. Cortical GM lesions may be present early in the disease course, and numerous, particularly in long-standing progressive MS. Cortical GM lesions are difficult to detect using current magnetic resonance imaging (MRI) techniques, but those observed are associated with physical and cognitive impairment. We investigated for in vivo evidence of cortical abnormalities by measuring the magnetisation transfer ratio (MTR) in a large cohort of MS patients of different clinical subtypes, and examined associations with clinical status.


Tina Holmes
Please email | millerpa@ucl.ac.uk