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13:00 - 14:00 21 November 2017

Experimental Psychology Seminar: Roles of hippocampus and neocortex in learning and memory in mice – from synapse to behaviour

Location

Room 305 | 26 Bedford Way (link Map)
London | WC1H 0DS | United Kingdom

Open to: Alumni | Public | Academic | Student

Michael Kohl, University of Oxford

Roles of hippocampus and neocortex in learning and memory in mice – from synapse to behaviour

Abstract: We recently identified a left-right dissociation of synaptic plasticity in the mouse hippocampus. To investigate possible effects on behaviour, we used optogenetics to unilaterally silence hippocampal CA3 pyramidal cells in mice performing hippocampus-dependent memory tasks. Whilst silencing of either the left or the right CA3 caused a short-term memory deficit, strikingly, only left CA3 silencing impaired long-term memory. Our data suggests that memory is routed via distinct left-right pathways within the mouse hippocampus. We are currently investigating whether this hemispheric specialisation extends to neocortical structures involved in associative memory.


Contact

UCL Department of Experimental Psychology
+44 (0) 207 679 5332 | h.spiers@ucl.ac.uk


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