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16:00 - 17:00 22 June 2017

WIBR Cafe Seminar: 'How do we sleep?'


Cruciform Cafe, 1st Floor Cruciform Building | Cruciform Building (link Map)
Gower Street | London | WC1E 6BT | United Kingdom

Open to: Academic | Student

Speaker: Professor William Wisden, Department of Life Sciences, Imperial College London

Host: Professor John Wood

In collaboration with Nick Franks at Imperial he has used mouse genetics to investigate how inhibition regulates the sleep-wake circuitry and the actions of sedative drugs, and has deployed a technique known as activity-tagging, or TetTagging, based on c-fos expression, for tracing and probing ensembles of neurons activated during sleep and by sedative drugs. Their major overarching question is: what mechanisms and neural circuitry make sleep inescapable when we are tired and deprived of sleep? In fact, the drive to "recovery sleep" after prolonged sleep deprivation seems so strong, that it is similar to taking a sedative drug. So, their second major question is: do sedative drugs cause loss of consciousness by activating the same mechanisms and circuitry responsible for this deep recovery sleep


Alison Kelly
Please email | alison.kelly@ucl.ac.uk