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17:30 - 18:30 30 July 2014

Lgr5+ stem cells in epithelial renewal and cancer

Location

Main Lecture Theatre | UCL Ear Institute (link Map)
332 Grays Inn Road | London | WC1X 8EE | United Kingdom

Open to: Academic

Speaker information


Prof Nick Barker, Senior Principle Investigator, Institute of Medical Biology in Singapore

The availability of robust cell-surface markers for identifying and isolating adult stem cells is essential for studying both their normal in-vivo function during tissue renewal and for evaluating their contribution to cancer. We have shown Lgr5, a Wnt target gene expressing a 7-TM receptor that functions as facultative component of the Wnt receptor complex, to selectively mark stem cells in a range of rapidly renewing tissues, including the small intestine, colon, stomach, hair follicle, ovary and developing kidney. Multicolor lineage tracing employing the stem cell-specific Lgr5-CreERT2 line has been used to further dissect how these adult stem cell pools maintain tissue homeostasis and contribute to tissue repair following damage. Targeted in-vivo mutation of the Lgr5+ve adult stem cell pools using the same Lgr5-CreERT2 model has been used to determine the contribution of stem cells to tumor initiation and progression in the gut. A summary of this work will be presented here.


Contact

Anne Oliphant
a.oliphant@ucl.ac.uk