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13:00 - 14:00 19 July 2018

CDB Seminar Series - Professor Benedikt Berninger

Location

G29, JZ Young LT | Anatomy Building (link Map)
Gower Street | London | WC1E 6BT | United Kingdom

Open to: Academic | Student

Title: "Engineering neurogenesis for the postnatal brain”

Speaker: Professor Benedikt Berninger - Institute of Physiological Chemistry of the University Medical Centerof the Johannes Gutenberg University Mainz

Host: Dr Richard Poole

Abstract: We explore the possibilities of generating new neurons where natural neurogenesis has ceased to occur, such as the postnatal or adult cerebral cortex. The approach we have taken is of lineage reprogramming glia or other brain-resident cells into induced neurons. Toward this end, we force the expression of developmentally relevant transcription factors to induce a neurogenic program. In this talk, I will discuss our efforts (1) to induce neurogenesis from glial cells in the postnatal mouse cortex in vivo, and (2) to decipher the molecular and cellular trajectory of adult human brain pericytes undergoing conversion into neurons.


Contact

Marilyn Bryan
020 7679 8015 (internal 08015) | m.bryan@ucl.ac.uk


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