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16:00 - 17:00 19 September 2018

CDCN Seminar: Modelling "normal" in the developing brain using MRI to detect pathology in prematurity and childhood


June Lloyd Room (link Map)
UCL GOS Institute of Child Health | London | United Kingdom

Open to: Academic | Student

Speaker: Dr Jonathan O'Muircheartaigh, Imaging & Biomedical Engineering, Kings College London

Abstract: In clinical neuroimaging, rapid developmental changes occurring in both clinical MRI contrasts and quantitative techniques can act to mask pathology when investigating the developing brain. When comparing groups, this can reduce statistical power, but when trying to detect tissue changes in individual infants and children, this effectively means that sensitivity to pathology can depend on the age of the individual being assessed and indeed can lead to differing patterns of false positive and negative changes.In this work, I’ll present both parametric and non-parametric approaches to address brain growth, creating pseudo-growth curves of brain tissue and shape development. I’ll use these techniques to better describe white matter pathology in the neonatal brain and subtle changes in the childhood brain.

All welcome to attend.


Katherine Ross
020 7905 2181 | katherine.ross@ucl.ac.uk