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13:00 - 14:00 3 May 2017

Pierre Pascal Lenck Santini seminar: Early Sharp Waves and oscillations in the Neonatal Rat Hippocampus


HO Schild Lecture Theatre | Medical Sciences and Anatomy Building (link Map)
Gower Street | London | WC1E 6BT | United Kingdom

Open to: Academic | Student

The neonatal (P2-P8) rat hippocampus in-vivo generates intermittent and spontaneous oscillatory activity patterns that are thought to participate in the functional maturation its circuits. These patterns consist of high amplitude (up to 1-2 mV), short lasting (50-200ms) early Sharp Waves (eSPWs) and beta (10-30Hz), 0.5-3s bouts of oscillations called tails. To better understand the functional role of such patterns, we addressed network mechanisms underlying their generation using a combination of Current Source Density, single unit analysis and stimulation protocols. We provide evidence that the eSPWs involve co-activation of the inputs both from CA3 and the entorhinal cortex and propose that during they support activity-dependent formation of connections in the developing entorhino-hippocampal network.


Francesca Cacucci