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16:00 - 17:30 19 April 2018

Recent Insights into the Molecular Mechanism of Synchronous Neurotransmitter Release at Synapses


Darwin Lecture Theatre | Darwin Building (link Map)
access via Malet Place | London | WC1E 6BT | United Kingdom

Open to: Alumni | Public | Academic | Student
Admission: Free
Ticketing: Ticketed and Pre-booking essential

Speaker information

James Rothman, Sterling Professor of Cell Biology, Yale School of Medicine, Professor James Rothman is one of the world's most distinguished biochemists and cell biologists as well as recipient of the 2013 Nobel Prize in Physiology or Medicine for his discoveries of machinery regulating vesicle traffic. He is Chairman of the Yale School of Medicine’s Department of Cell Biology and is the Director and founder of the Nanobiology Institute on Yale’s new West Campus. Professor Rothman discovered key molecular machinery responsible for transfer of materials among compartments within cells, providing the conceptual framework for understanding such diverse and important processes as the release of insulin into the blood, communication between nerve cells in the brain, and the entry of viruses to infect cells.

It has long been known that SNARE proteins mediate the fusion of synaptic vesicles and that this is triggered when the calcium sensor synaptotagmin is activated. But how these processes are coupled to synchronize synaptic neurotransmission to the action potential remains a mystery. Equally vexing is the required speed of this release, occurring in under a millisecond, a thousand times faster than the intrinsic speed of individual SNARE proteins. Recent collaborative research at UCL and Yale has resulted in a coherent hypothesis based that promises to solve both problems.


Rachel Hall
+44 (0)20 3108 6974 | rachel.hall@ucl.ac.uk


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