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16:00 - 17:00 12 September 2014

The genetic basis for cellular diversity in the mouse cortex

Location

Gavin de Beer Lecture Theatre | Anatomy Building (link Map)
Gower Street | London | United Kingdom

Open to: Academic | Student

Speaker information: Jens Hjerling-Leffler, Karolinska Institutet, Sweden. Host: Professor Kenneth D. Harris. Abstract: The normal function of the mammalian brain relies on the proper assembly of a diverse set of neuronal cell types as well as glia and vasculature. Our lab is focused on understanding how genetics are coupled to functional diversity. In our latest effort we have used large-scale single-cell RNA-seq to define cellular subtypes in the primary sensory cortex (S1) and the CA1 region of the mouse cortex. Using immunohistochemistry, in situ hybridization and RNA single-molecule FISH, we have confirmed quantitative and qualitative properties of our data independently and linked several our identified subclasses to morphologically and spatially defined cell types.


Contact

Professor Kenneth D. Harris
kenneth.harris@ucl.ac.uk


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