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13:00 - 14:00 28 September 2018

Ear Institute talk


Main seminar room (link Map)
UCL Ear Institute | London | United Kingdom

Open to: Academic | Student

Speaker: Andrei S. Kozlov, Department of Bioengineering, Imperial College London 'Gating without swinging: a two-channel model of hair-cell mechanotransduction with membrane-mediated cooperativity'

Sound-induced vibrations of the inner ear stretch tip links between stereocilia of hair cells and open mechanotransduction ion channels. Channel opening in turn relaxes the tip links. The classical gating-spring model ascribes this gating compliance to the conformational change of a single mechanotransduction channel upon gating, known as the gating swing. To reproduce the experimental data, however, the magnitude of the gating swing must be comparable to, or even greater than, the size of a typical ion channel. Experimental evidence indicates that each tip link is associated on average with two channels, and that the lipid bilayer modulates their gating, although it is not clear how....


Roland Schaette
Please email | r.schaette@ucl.ac.uk