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13:00 - 14:00 21 January 2013
SODIUM CHANNELS AND EPILEPSY: INSIGHTS INTO PHYSIOLOGY AND MECHANISMS
Kennedy Lecture Theatre |
UCL Institute of Child Health
30 Guilford Street | London | WC1N 1EH |
odium channels and epilepsy: Insights into physiology and mechanisms
Voltage-gated sodium channels play essential roles in normal neurological function especially in initiation and firing of action potentials. It is, therefore, not surprising that gene variation can have effects, and even potentially devastating consequences on the nervous system. Indeed, sodium channel mutations are the most important currently recognized cause of genetic epilepsies.
The associated phenotypic variation is remarkable – from mild febrile seizures to devastating infantile encephalopathies. In this lecture I briefly review the neurobiology of sodium channels, discuss their known mutational spectrum in epilepsies and explore the challenges in functional characterization to help clarify the complex genotype-phenotype correlations.
Professor Sam Berkovic University of Melbourne Brain Research Institute Epilepsy Research Centre Please email queries to firstname.lastname@example.org
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