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12:00 - 13:00 26 June 2018

SWC Seminar: Dysregulation and restoration of neuronal circuit activities in Alzheimer models


Ground floor Lecture Theatre, Sainsbury Wellcome Centre (link Map)
5 Howland Street, | London | W1T 4JG | United Kingdom

Open to: Academic | Student

Speaker: Dr Marc Busche, Alzheimer's Disease Research Unit, Harvard Medical School & Massachusetts General Hospital Host: Troy Margrie, Associate Director

No need to book, just turn up.

Abstract: There is a real urgency to better understand the complexeties of Alzheim's disease, with a population aging and no effective treatments available. Alzheimer is manifest neuropathologically by both amyloid-ß plaques and tau containing neurofibrillary tangles; however, the mechanisms by which those brain lesions initiate and drive the disease remain uncertain. In my talk, I will present data, mostly from in vivo two-photon calcium imaging in mouse models, that show how Alzheimer neuropathology causes massive impairments in neuronal circuit physiology that lead to memory problems – and that such impairments can be reversed only under certain conditions, which has important implications for clinical trials in patients.


Sainsbury Wellcome Centre Events
+44 20 3108 8004 | swc-events@ucl.ac.uk


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