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12:00 - 13:00 12 January 2017
Autoimmunity and the genetics of immunological paranoia viewed through the prism of immunodeficiency
Royal Free Campus
Rowland Hill Street | Hampstead | London | NW3 2PF | United Kingdom
Part of the UCL Institute of Immunity and Transplantation Seminar Series.
Speaker: Prof Peter Lane, University of Birmingham.
Peter Lane is Professor of Clinical Immunology in the Institute of Immunology and Immunotherapy at the University of Birmingham. He is interested in the molecular and cellular basis of CD4 T cell memory and effector function, particularly in the context of human susceptibility to autoimmune disease. Checkpoint inhibitors that suppress normal mechanisms that maintain self-tolerance, have been effective in revealing CD8 responses against cancers with high mutation loads, but at the cost of off target, primarily CD4 driven, autoimmunity which can be lethal. In his MRC funded research he has identified OX40 blockade as being effective in abrogating this “acute” inflammation without compromising anti-tumour immunity driven by CD8 T cells.
Please contact Prof Lucy Walker (firstname.lastname@example.org) if you would like to meet the speaker.
All are welcome.
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