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16:00 - 17:00 27 January 2016
Characterizing the neuropharmacology of alcoholism with neuroimaging to improve treatment
Malet Place | London | WC1E 7JE | United Kingdom
Anne Lingford-Hughes, Professor of Addiction Biology, Imperial College Faculty of Medicine
Speaker: Professor Anne Lingford-Hughes.
This lecture will describe our recent studies using PET and fMRI to characterize the neuropharmacology of alcoholism, focusing on the opiate and dopamine D3 system. Using PET we have previously shown higher availability of mu opiate receptors and higher availability of dopamine D3 receptors in abstinent alcohol dependence. We established an experimental medicine platform with Universities of Manchester and Cambridge using fMRI and selective pharmacological tools to explore the neuropharmacology of putative relapse pathways in cocaine, alcohol, opiate dependent and healthy individuals to inform future drug development. I will describe how the opiate antagonists naltrexone and nalmefene and dopamine D3 antagonist impact on the relapse pathways such as reward in alcoholism. Using such approaches will inform future drug development and help target current treatments more effectively.
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