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17:00 26 May 2017

Z. Josh Huang: 'Transcriptional architecture of cortical GABAergic neuron types'


Gavin de Beer Lecture Theatre, G04 | Anatomy Building (link Map)
Gower Street | London | WC1E 6BT | United Kingdom

Open to: Academic | Student

Speaker: Z. Josh Huang, Cold Spring Harbor Labs

Understanding the biological basis of neuronal diversity and identity is necessary for deciphering the functional organization of brain circuits. A fundamental question is whether phenotypic variations of neurons are largely subjective to measurements and can only be managed by operational grouping, or whether congruent cell features can be integrated to define discrete “types” that reflect biological reality and mechanisms. Based on high resolution single cell transcriptome analysis, I will present evidence that cortical interneuron types can be delineated by their input-output communication styles, likely supported by coherent expression of select members of a relatively small number of gene families. I will use cortical chandelier cells as an example to demonstrate the fine granularity of unitary interneuron types and their exquisite input-output connectivity pattern.


Kenneth D. Harris